Nck2 is essential for limb trajectory selection by spinal motor axons
نویسندگان
چکیده
منابع مشابه
SRC family kinases are required for limb trajectory selection by spinal motor axons.
Signal relay by guidance receptors at the axonal growth cone is a process essential for the assembly of a functional nervous system. We investigated the in vivo function of Src family kinases (SFKs) as growth cone guidance signaling intermediates in the context of spinal lateral motor column (LMC) motor axon projection toward the ventral or dorsal limb mesenchyme. Using in situ mRNA detection w...
متن کاملCoordinate Roles for LIM Homeobox Genes in Directing the Dorsoventral Trajectory of Motor Axons in the Vertebrate Limb
Motor neurons extend axons along specific trajectories, but the molecules that control their pathfinding remain poorly defined. We show that two LIM homeodomain transcription factors, Lim1 and Lmx1b, control the initial trajectory of motor axons in the developing mammalian limb. The expression of Lim1 by a lateral set of lateral motor column (LMC) neurons ensures that their axons select a dorsa...
متن کاملMotoneuronal Sema3C is essential for setting stereotyped motor tract positioning in limb-derived chemotropic semaphorins.
The wiring of neuronal circuits requires complex mechanisms to guide axon subsets to their specific target with high precision. To overcome the limited number of guidance cues, modulation of axon responsiveness is crucial for specifying accurate trajectories. We report here a novel mechanism by which ligand/receptor co-expression in neurons modulates the integration of other guidance cues by th...
متن کاملSelective innervation of transplanted limb muscles by regenerating motor axons in the axolotl.
The segmental pattern of motor innervation of hindlimb muscles in the axolotl was studied before and after reinnervation. To ascertain the specificity of reinnervation, the four spinal nerves innervating the hindlimb were severed and allowed to regenerate. The segmental origin of axons reinnervating particular muscles was then determined by intracellular recording from muscle fibers. Muscles we...
متن کاملnsf Is Essential for Organization of Myelinated Axons in Zebrafish
BACKGROUND Myelinated axons are essential for rapid conduction of action potentials in the vertebrate nervous system. Of particular importance are the nodes of Ranvier, sites of voltage-gated sodium channel clustering that allow action potentials to be propagated along myelinated axons by saltatory conduction. Despite their critical role in the function of myelinated axons, little is known abou...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 2018
ISSN: 1058-8388
DOI: 10.1002/dvdy.24656